International Civil Aviation Organization (ICAO), COVID-19 Aviation Scientific Advisory Group (CASAG), COVID Literature Reviews

Vaccination and its Effect on SARS-CoV2 Onward Transmission: A Narrative Review: International air travel has been drastically reduced in the face of the COVID-19 pandemic. Aviation organizations are concerned to understand when re-opening of quarantine-free travel may be safely achieved for vaccinated travellers. With over 1.5 billion vaccines now having been administered worldwide, there is a need to understand to what extent vaccination can prevent transmission. This could inform guidance on how to introduce vaccination as an extra layer of the multi-layered strategy, with a view to safely avoiding or reducing quarantine requirements. The pre-requisite question is: how effective is vaccination in preventing SARS-CoV2 transmission – with the subsidiary question, different but related: how effective is vaccination in preventing asymptomatic infection? Duration of immunity following SARS-CoV2 infection: A narrative review. As international aviation implements travel pathways that are influenced by vaccination and recovery from previous COVID-19 infection, aviation organizations need to understand the duration of effective immunity following SARS-CoV-2 infection. In particular, within the multi-layered risk mitigation strategy, where previous infection is known to greatly reduce the risk of contracting or transmitting SARS-CoV-2, this could inform guidance on the suitable maximum duration of certificates of recovery. Naturally acquired active immunity occurs when an individual is exposed to SARS-CoV-2 virus, becomes infected, and develops protective immunity as a result of the primary immune response. The adaptive immune response generated against the virus takes days or weeks to develop but may be long-lasting. This narrative review aims to inform how long naturally acquired immunity against SARS-CoV-2 lasts, as reported in the best scientific evidence available to date.


    • English


    • Status: Active
    • Contract Numbers:


    • Sponsor Organizations:

      Department of Transportation

      1200 New Jersey Avenue, SE
      Washington, DC  United States  20590
    • Managing Organizations:

      Federal Aviation Administration

      800 Independence Avenue, SW
      Washington, DC  United States  20591
    • Performing Organizations:

      Civil Aerospace Medical Institute-Federal Aviation Administration

      P.O. Box 25082
      Oklahoma City, OK  United States  73125
    • Principal Investigators:

      DeJohn, Charles

    • Start Date: 20210518
    • Expected Completion Date: 20211231
    • Actual Completion Date: 20211231
    • USDOT Program: Aeromedical Research
    • Subprogram: aviation safety

    Subject/Index Terms

    Filing Info

    • Accession Number: 01782617
    • Record Type: Research project
    • Source Agency: Federal Aviation Administration
    • Contract Numbers: N/A
    • Files: RIP, USDOT
    • Created Date: Sep 22 2021 3:34PM