Comparison Across Multiple Types of Sleep Loss

This fatigue study is designed to assess neurobehavioral performance, as well as genetic and other physiological changes associated with variations in timing and quantity of sleep. Molecular correlates of cognitive changes will be assessed among individuals randomly assigned to four separate sleep conditions: a well-rested control, sleep restriction, nighttime sleep to roughly simulate shiftwork schedules, and total (acute) sleep deprivation. This study will generate a core deliverable of an internal biomarker list, and possible extramurally supported additional reports or datasets. Physiological and performance information collected include wearable actigraphy data, polysomnography data, and neurobehavioral performance data.