Structure Dynamics-Guided Biocatalyst Improvement

The success in the proposed research will open a new chapter in biocatalyst improvement and greatly benefit the biorefinery industry with three folds. First, the project team will deliver a novel platform using Hydrogen Deuterium Exchange (HDX) mass spectrometry for biocatalyst improvement, and the platform can be used for enzyme improvement of various purposes. Second, the team will be able to deliver some biocatalysts with higher efficiency and better inhibitor resistance. These biocatalysts will help to improve the biorefinery procedure and biomass conversion efficiency tremendously. Third, the proposed research will help to elucidate the molecular mechanisms for the cellulase enzyme catalysis and inhibition from the dynamic perspectives, which will guide the future enzyme improvement.

  • Supplemental Notes:
    • Program Information: Advanced Research, Biobased Research


  • English


  • Status: Completed
  • Funding: $63436.00
  • Sponsor Organizations:

    Research and Innovative Technology Administration

    Department of Transportation
    1200 New Jersey Avenue, SE
    Washington, DC  United States  20590
  • Project Managers:

    Johnson, Shawn

  • Performing Organizations:

    Texas A&M University, College Station

    College Station, TX  United States  77840
  • Principal Investigators:

    Yan, Joshua

    Dai, Susie

  • Start Date: 20090701
  • Expected Completion Date: 0
  • Actual Completion Date: 20110630
  • Source Data: RiP Project 31377

Subject/Index Terms

Filing Info

  • Accession Number: 01572206
  • Record Type: Research project
  • Source Agency: Department of Transportation
  • Files: RIP
  • Created Date: Aug 4 2015 1:00AM